Table 1.

Substrates of HAUSP

Interacting partners	Functional and pathological consequences	Disease context
p53,12 MDM2,13,14 DAXX,43,94,95 Rb,33 TSPYL5,34 Nucleolin,96 STIP,97 HIF-1α,85 Ki-67,38 WDR79,39 Geminin.44	Regulation of cell growth, apoptosis and tumorigenesis, hypoxia.	Cancer—breast, colon, lung, osteosarcoma, etc.
ICP0,10 EBNA1,50 vIRF1,48 vIRF4,63 LANA,64 UL35 and UL35a,64 E1B-55K,65 NFκB,87 FoxP3,88 TRAF6,24 NEMO,24,91 Nek2.92	Host-virus interactions, inflammation, immune functions, and cancer signaling	Viral infection and associated cancers—Burkitt’s lymphoma, Hodgkin’s lymphoma, HSV-1 infection, Kaposi’s sarcoma, nasopharyngeal carcinoma, etc.
PPAR-γ,54 FOXO1.55	Regulation of adipogenesis, osteogenesis, glucose and lipid metabolism	Metabolic disorders and diabetes
Ci/Gli,90 REST.52	Positive regulation of Hedgehog signaling; neurodevelopment; development	Development, cancer and neurodegeneration
Cry1 and 2,68 Chk1,69 Claspin,70 Chfr,71 MCM-BP.69	Regulation of genome integrity and stability	Development, cancers—colon, glioma, osteosarcoma, etc.
Tip60,72 CCDC6,40 RNF168,74 ANXA1,75 Polη,58 Rad18,75 PCNA,58 UVSSA and ERCC6,59 PHF8.45	Replication, DNA damage signaling and DNA repair processes	UV-sensitive syndrome and cancers, oxidative stress, DNA damage, etc.
MEL18 and BMI1,77 GMPS,78,90 DNMT1,41,79–81 ASXL1,82 AR,83 SUV39H1,84 Rae1, Bub3 and Nup98.36	Epigenetic regulation—chromatin dynamics and gene expression	Cancers—breast, cervical, colon, lung, prostate, MDS, etc.
PTEN,27,46,47 FoxO3a and 4,61 FoxO6,100 PML,60 TRRAP,98 TRIP12,30 MEX-3C,99 β-catenin,42 RNF220,93 MARCH7.31	Modulation of cellular signaling for tumorigenesis or tumor suppression	Cancers—epithelial ovarian, hepatocellular, leukemia, lung, osteosarcoma, prostate, etc.
Alix/Hp95,89 MAGE-L2-TRIM27- WASH.37	Endosomal protein trafficking	Multiple cancers

Table showing different substrates of HAUSP, the functional and pathological consequences