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. 2018 Jun 28;8:9788. doi: 10.1038/s41598-018-27948-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantifying changes in focal adhesion morphology. Mean focal adhesion area, length and eccentricity as a function of strain (A), (C), (E), and as a function of time in control experiments at a constant strain of 13% (B), (D), (F). As a reference, in horizontal dashed-red line, the value of the magnitude in the stretching experiment at the initial condition (13% normal strain). *Indicates p-value < 0.05, Mann-Whitney test between the conditions connected with a horizontal line. (G) Average focal adhesion area change as a function of strain. Expected substrate length change is shown in dashed-blue line, and expected cell area change in dotted-green line. (H) Average focal adhesion length change as a function of strain. Linear fit is presented in red line and expected substrate length change in dashed-blue line. N = 55 focal adhesions from 4 cells for stretching experiment, and N = 19 focal adhesions from 4 cells for control time lapse experiments; s.e.m. as error bars.