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. 2018 Jun 28;8:9788. doi: 10.1038/s41598-018-27948-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Zyxin translocation in response to mechanical strain. Representative confocal images of HC11 cells expressing zyxin-EGFP at 13% (A), 30% normal strain (B), and cultured on coverglass (C). Besides its location at focal adhesions, in both cases under strain (A,B), zyxin is typically found to be located along actin filaments (indicated by red arrows); while in cells maintained at a constant strain, such as cells cultured on coverglass, zyxin has approximately the same probability of being found or not along actin filaments. In the case presented in (C), zyxin was only located at focal adhesions. On top of each panel, is displayed the percentage of cells showing zyxin translocation to actin filaments. Entire cell images scale bars: 20 μm; zoomed images scale bar: 5 μm. N = 23 cells were analyzed at 13% of strain, N = 23 cells at 30% of strain, and N = 52 cells cultured on coverglass.