Table 2.
SNPs effect on the reporter activity of the HPSE gene enhancer
| Cell lines | SNP variants (sense) | p value | SNP variants (antisense) | p value |
|---|---|---|---|---|
| U226 | A–B | 0.0003 | A–B | 0.006 |
| A–C | 0.008 | A–C | 0.004 | |
| B–C | 0.04 | B–C | 0.0004 | |
| CAG | A–B | NS | A–B | NS |
| A–C | 0.01 | A–C | 0.002 | |
| B–C | 0.01 | B–C | 0.003 | |
| RPMI8226 | A–B | 0.0003 | A–B | 5.8 × 10−6 |
| A–C | 0.02 | A–C | 3.8 × 10−7 | |
| B–C | 0.0001 | B–C | 0.7 × 10−5 | |
| KG-1 | A–B | NS | A–B | 3.1 × 10−6 |
| A–C | NS | A–C | 9.1 × 10−7 | |
| B–C | NS | B–C | NS | |
| REH | A–B | 0.0003 | A–B | NS |
| A–C | 0.0005 | A–C | 0.02 | |
| B–C | 2.48 × 10−5 | B–C | NS | |
| HT-1080 | A–B | 0.001 | A–B | 0.0001 |
| A–C | NS | A–C | 9.98 × 10−5 | |
| B–C | 0.002 | B–C | NS | |
| A459 | A–B | 0.0001 | A–B | NS |
| A–C | 0.06 | A–C | 0.03 | |
| B–C | 0.0003 | B–C | NS | |
| H1229 | A–B | 0.05 | A–B | 0.001 |
| A–C | NS | A–C | NS | |
| B–C | 0.04 | B–C | 0.004 | |
| PC-3 | A–B | 0.0004 | A–B | 0.06 |
| A–C | NS | A–C | NS | |
| B–C | 0.0003 | B–C | NS |