Table 3.
Expression of TFs, miRNAs, mRNAs, and LINC01764 after U0126 Treatment
| miRNAs Targeting mRNAs Co-expressed with UCA1 | mRNAs/miRNAs | 6 hr | 12 hr | 24 hr | 48 hr |
|---|---|---|---|---|---|
| – | miR-135a | 1.38 (0.24) | −1.03 (0.82) | 1.12 (0.73) | −1.73 (0.14) |
| – | miR-143 | 1.29 (0.15) | 1.5 (0.028)a | 1.56 (0.027)a | 1.16 (0.43) |
| – | miR-214 | −1.94 (0.88) | −2.34 (0.23) | 1.13 (0.61) | 3.14 (0.02)a |
| – | miR-1271 | 1.23 (0.21) | 1.03 (0.71) | 1.31 (0.91) | −1.36 (0.14) |
| miR-135a, miR-214, miR-1271 | ANLN | −1.38 (0.41) | −1.02 (0.6) | −1.21 (0.26) | −4.19 (0.039)a |
| miR-135a, miR-143 | BIRC5 | −4.19 (0.032)a | 1.23 (0.61) | 1.74 (0.23) | 4.57 (0.008)a |
| miR-135a, miR-143, miR-214 | CD46 | 1.55 (0.23) | −1.76 (0.05)a | 2.13 (0.014)a | 1.27 (0.07) |
| miR-135a, miR-214 | DEK | −4.3 (0.014)a | −1.15 (0.5) | −1.31 (0.18) | −1.26 (0.2) |
| miR-143 | DNMT3A | −1.87 (0.11) | 1.41 (0.75) | 1.92 (0.009)a | 1.15 (0.72) |
| miR-143, miR-1271 | HMMR | −2.13 (0.17) | −1.01 (0.59) | 1.34 (0.005)a | −2.62 (0.07) |
| miR-214 | IPO7 | −1.13 (0.41) | −1.35 (0.25) | 1.77 (0.09) | 1.08 (0.84) |
| miR-135a, miR-143, miR-1271 | KIF23 | −1.87 (0.19) | −1.25 (0.28) | 1.2 (0.17) | −2.53 (0.05)a |
| – | LINC01764 | −2.65 (0.08) | −1.22 (0.23) | 2.83 (0.004)a | 4.8 (0.008)a |
| miR-143 | MACC1 | −3.11 (0.05)a | 1.4 (0.034)a | 2.55 (0.0006)a | 1.54 (0.06) |
| miR-143 | MMP7 | 5.01 (0.25) | 2.37 (0.06) | 2.2 (0.09) | 1.19 (0.83) |
| miR-135a | MYC | −5.29 (0.013)a | −4.98 (0.023)a | 1.25 (0.08) | 2.21 (0.09) |
| – | CEBPB | −3.39 (0.01)a | −1.08 (0.55) | 2.08 (0.001)a | 1.72 (0.046)a |
| – | TEAD4 | −1.99 (0.049)a | −1.28 (0.21) | 3.43 (0.002)a | 1.64 (0.07) |
Median fold change and t test p-value (in parentheses) are shown.
a
Statistically significant.