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. 2018 Jun 22;9:1462. doi: 10.3389/fimmu.2018.01462

Table 1.

Aberrant expression of IL-38 in rheumatic autoimmune diseases.

Animal models/patient data Diseases Increase/decrease compared with controls Reference
Serum levels of IL-38 in patients SLE Increase (9)
IL-38 mRNA expression in spleen, thymus from mice models SLE Decrease (8)
mRNA and protein levels of IL-38 in labial salivary from patients pSS Increase (31)
Serum concentrations of IL-38 in patients Psoriasis Increase (12)
IL-38 mRNA expression in skin from mice models Psoriasis Decrease (10, 35)
IL-38 mRNA levels in synovial fluid from patients RA Increase (10, 11)
IL-38 mRNA expression in joints from mice models RA Increase (10, 11)
mRNA levels of IL-38 in colon from patients CD Increase (10)
mRNA levels of IL-38 in colon from mice models CD Increase (10)

SLE, systemic lupus erythematosus; pSS, primary Sjögren’s syndrome; RA, rheumatoid arthritis; CD, Crohn’s disease.