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Proposed model for the role of ICOS in pathogenic T cells and Tregs in cGVHD. Abbreviations: APCs, antigen-presenting cells; eTfh, extrafollicular T helper cells; Bcl-6, B-cell lymphoma 6; Foxp3, forkhead box P3; RORγt, retinoic acid receptor-related (RAR) orphan; TCF-1, T cell factor 1; cGVHD, chronic graft-versus-host disease; ICOS, inducible T-cell co-stimulator; Tregs, regulatory T cells.
