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. 2018 Jun 22;9:1461. doi: 10.3389/fimmu.2018.01461

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Copyright © 2018 Zhang, Wu, Bastian, Iamsawat, Chang, Daenthanasanmak, Nguyen, Schutt, Dai, Chen, Suh and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inducible T-cell co-stimulator (ICOS) promotes follicular regulatory T (Tfr) development. Bone marrow transplantation (BMT) was setup as described in Figure 4. Splenocytes were analyzed by flow cytometry at 60 days after BMT. Representative contour plots of individual mice and mean percentage of T follicular helper (Tfh) cells (PD-1⁺CXCR5⁺) on gated H-2K^b+CD4⁺Foxp3⁻ and Tfr cells (PD-1⁺CXCR5⁺) on gated H-2K^b+CD4⁺Foxp3⁺T cells are shown (A), n = 4–5 mice/group. Representative contours plots of each group and mean percentage of B220⁺ and B220⁻CD138⁺ plasma cells on gated H-2K^b+ cells, GL-7⁺Fas⁺ germinal center B cells (GCs) gated on H-2K^b+B220⁺ cells are shown (B,C), n = 4–6 mice/group. Representative histograms and mean fluorescence intensity (MFI) of CD86 and CD40 gated on H-2K^b+B220⁺ cells are shown (D). *p < 0.05 and **p < 0.01.