Figure 2.

Representation of LAT1/CD98 and its substrates. The protein heterodimer is asymmetrically inserted in the cell membrane. The double-face feature of LAT1 is indicated by two-color design of the model. The blue half represents the specificity toward amino acids which are colored in blue (Essential Amino Acids) and light blue (Non-Essential Amino Acids). The size is suggestive of the higher or the lower specificity toward the amino acids. The red half represents the known specificity toward non-amino acid substrates: hormones, drugs and inhibitors. The reactivity of –SH group(s) of the protein toward Hg²⁺ is also represented. Glycosylation of CD98 is depicted as “antennas”.