Figure 4.

The input-output circuits of the BF-ACh neurons and the LC-NA neurons. (A) BF cholinergic neurons project selectively to different brain regions based on their input regions (Gielow and Zaborszky, 2017). Each color represents the selective input-output relationship of the BF ACh neurons. Cortical and subcortical inputs are shown in the gray boxes. (B) LC noradrenergic neurons receive converging inputs and show diverging projections to various brain areas (Schwarz et al., 2015). The PFC is one of the strong cortical inputs, although the cortical afferent to the LC is relatively weaker than the subcortical afferent. The asterisk (*) refers the Figure 2B where the noradrenergic projection to the PFC is selective rather than diverging in rats (Chandler et al., 2013).