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. 2018 Jun 22;9:1381. doi: 10.3389/fmicb.2018.01381

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Copyright © 2018 Koehler, Cornely, Wisplinghoff, Schauss, Salmanton-Garcia, Ostermann, Ziegler, Bacher, Scheffold, Alex, Richter and Koehler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequencies of Candida-reactive T cells in healthy donors, disease control and patients with probable or proven invasive Candida infection. Patients with proven invasive Candida infection had a simultaneous 3.05-fold increase of antigen-stimulated T cells compared to unstimulated T cells to exclude false positive results and to determine quality of the stimulation. Dashed lines show cut-off values for C. albicans-reactive T cells (0.40%) and C. glabrata-reactive T cells (0.22%), respectively. Healthy donor n = 14, disease control n = 9. (A) Frequencies of C. albicans CD69⁺/CD154⁺ T cells among CD4⁺ T cells in donor/patient cohorts. Given is the highest frequency during the test series. (B) Frequencies of C. glabrata CD69⁺/CD154⁺ T cells among CD4⁺ T cells in donor/patient cohorts. Given is the highest frequency during the test series.