Table 1.
Trial/year | Sample size | Mean age (men/women) | Patient entry criteria | Experiment group | Control group | Treatment duration | Outcome measures |
---|---|---|---|---|---|---|---|
Zhou, 2010 | Exp:63 | 61–87 | NP | Ginkgo biloba tablet 480 mg/d | Atorvastatin 20 mg/d | 26 weeks | TG, TC, LDL-C, HDL-C |
Con:62 | (66/59) | LDL-C ≥ 3.4 mmol/L, TG ≥ 1.7 mmol/L | LDL-C ≥ 3.4 mmol/L, TG ≥ 1.7 mmol/L | ||||
Guo and Ju, 2011 | Exp:40 | 46–79 | TC ≥ 5.72 mmol, | Ginkgo biloba pill 480 mg/d + | Atorvastatin 20 mg/d | 24 weeks | TC, LDL-C, HDL-C, AE |
Con:39 | (44/36) | LDL-C ≥ 3.64 mmol/L, and/or HDL-C ≤ 1.04 mmol/L | atorvastatin 20 mg/d | ||||
Zhong and Bao, 2011 | Exp:30 | 39–78 | TC ≥ 5.2 mmol, | Ginkgo biloba tablet 240 mg/d | Atorvastatin 10 mg/d | 6 weeks | TG, TC, LDL-C, HDL-C |
Con:29 | (29/30) | LDL-C ≥ 3.64 mmol/L, TG ≥ 1.7 mmol/L | + atorvastatin 10 mg/d | ||||
Lin et al., 2011 | Exp:32 | 28–76 | TC ≥ 5.2 mmol, | Ginkgo biloba tablet 240 mg/d | Atorvastatin 10 mg/d | 6 weeks | TG, TC, LDL-C, HDL-C, AE |
Con:32 | (35/29) | LDL-C ≥ 3.4 mmol/L, TG ≥ 1.7 mmol/L | + atorvastatin 10 mg/d | ||||
Jin et al., 2012 | Exp:33 | 36–71 | TC ≥ 5.2 mmol, | Ginkgo biloba tablet 240 mg/d | Rosuvastatin 10 mg/d | 4 weeks | TG, TC, LDL-C, HDL-C, AE |
Con:32 | (36/29) | LDL-C ≥ 3.64 mmol/L, TG ≥ 1.7 mmol/L | + rosuvastatin 10 mg/d | ||||
Ren, 2012 | Exp:41 | Exp:54.8 ± 3.2/(NP) | TC ≥ 5.2 mmol, | Ginkgo biloba tablet 576 mg/d | Simvastatin 20 mg/d | 8 weeks | TG, TC, LDL-C, HDL-C |
Con:41 | Con:59.1 ± 4.6/(NP) | LDL-C ≥ 3.4 mmol/L, TG ≥ 1.7 mmol/L | + simvastatin 20 mg/d | ||||
Zhu, 2012 | Exp:65 | 42–78 | TC ≥ 5.752 mmol, | Ginkgo biloba capsule | Simvastatin 10 mg/d | 6 weeks | TG, TC, LDL-C, HDL-C |
Con:65 | (62/58) | LDL-C ≥ 3.64 mmol/L, and/or HDL-C ≤ 1.04 mmol/L, TG ≥ 1.7 mmol/L | 120 mg/d + simvastatin 20 mg/d | ||||
Xu, 2013 | Exp:30 | 47–80 | TC ≥ 5.2 mmol, | Ginkgo biloba tablet | Simvastatin 20 mg/d | 8 weeks | TG, TC, LDL-C, HDL-C |
Con:30 | (37/23) | LDL-C ≥ 3.4 mmol/L, TG ≥ 1.7 mmol/L | 240 mg/d + simvastatin 20 mg/d | ||||
Exp, experiment; Con, control; TGs, triglycerides; TC, total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.