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The INV region is not required for the IRS2-dependent regulation of glucose uptake. PyMT:Irs1/2−/− cells were grown in 0.1% BSA-DMEM with or without IGF-1 (25 ng/ml) for 16 to 24 h. Glucose uptake was measured and normalized to cell density. The data shown represent the means ± SEM of the results of five independent experiments. *, P < 0.05 relative to EV; #, P < 0.05 relative to unstimulated.
