Fig. 5. Effects of compound 1 on other PDEs. The enzymatic activities of different PDEs with or without compound 1 were analyzed by HPLC or bis-pNPP cleavage assays. Compound 1 did not significantly inhibit YahA from E. coli, PA4108, PvrR or DipA from P. aeruginosa and snake venom phosphodiesterase (SVPD) from Crotalus atrox. Experimental condition is described in Methods.† .
