Table 1. Optimization of reaction conditions using alkynyl bromide ^a .

Entry	Cat (mol%)	Additive (equiv.)	Solvent	Temp (°C)	Yield b (%)
1	Pd(OAc)2 (10)	AgOAc (1)	Toluene	90	N.R.
2	Pd(OAc)2 (10)	AgOAc (1)	DCE	90	40
3	Pd(OAc)2 (10)	AgOAc (2)	DCE	90	67
4	Pd(OAc)2 (10)	AgOAc (3)	DCE	90	90
5	Pd(OAc)2 (10)	AgOAc (3)	DCE	80	70
6	Pd(OAc)2 (10)	AgOAc (3)	DCE	100	75
7	Pd(OAc)2 (5)	AgOAc (3)	DCE	90	89
8	Pd(OAc)2 (2.5)	AgOAc (3)	DCE	90	78
9	Pd(TFA)2 (5)	AgOAc (3)	DCE	90	82
10	Pd(OAc)2 (5)	Ag2CO3 (2)	DCE	90	75
11	Pd(OAc)2 (5)	Ag2O (2)	DCE	90	63
12	Pd(OAc)2 (5)	AgNO3 (3)	DCE	90	30

^aReactions were conducted on a 0.05 mmol scale in 0.5 mL of solvent in a closed flask for 6 h; DCE = 1,2-dichloroethane; TFA = trifluoroacetate.

^bGC yields.