Table 2.

Examples of the natural compound with histone deacetylase inhibitory activity.

S.N	Class of Compounds	Name of the Compound	HDAC Target	Source (Species/Family)	Structure	Reference
1.	Phenolics	Aceroside VIII	HDAC6	Betula platyphylla		[87]
		Homobutein	Class I, II and IV	Butea frondosa		[88]
		Isoliquiritigenin	Class I, II and IV	Glycyrhiza glabra		[89]
		Butein	Class I, II and IV	Toxicodendron vernicifluum		[88]
		Kaempferol	Class I, II and IV	Aloe vera		[89]
		Marein	Class I, II and IV	Coreopsis maritima		[88]
		Protocatechuic aldehyde	HDAC2	Hordeum vulgare		[23]
		Psammaplin A	Class I	Poecillastra spp. and Jaspis spp.		[23]
		Sinapinic acid	Pan-HDAC	Hydnophytum formicarum Jack		[90]
		Resveratrol	Class I, II and IV	Vitis vinifera		[91]
2.	Polyketides	Depudecin	HDAC 1	Alternaria brassicicola		[92]
3.	Tetrapeptide	Apicidin	Class I HDAC	Fusarium spp.		[93]
		Azumamide E	Class I	Mycale izuensis		[94]
		Chlamydocin	HDAC 1, 6	Diheterospora chlamydosporia		[95]
		Trapoxin A	Class I	Helicoma ambiens RF-1023		[96]
4.	Terpenoids	Zerumbone	Pan HDAC	Zingiber zerumbet		[23]
		β-Thujaplicin	HDAC 2	Cupressaceae spp.		[23]
		6-methoxy-2E,9E-humuladien-8-one	Pan HDAC	Zingiber zerumbet		[23]
5.	Alkaloid	Lycorine	Pan HDAC	Amaryllidaceae		[97]
6.	Fatty acid	9-Hydroxystearic acid	Class I	Lipid peroxidation product		[98]
7.	Organosulphur compounds	Diallyl disulfide	Acetylation Level increased	Allium sativum		[99,100]
		(S)-allylmercaptocysteine		Allium sativum		[101]
8.	Hydroxamic acid	Trichostatin A	Class I and II	Streptomyces hygroscopicus		[2,11]
9.	Desipeptides	FK228	HDAC 1, 2	Chromobacterium violaceum		[11]
		Largazole	Class I	Symploca spp.		[99]