Table 2.
Characteristics of patients with MC by subtype.
| Total (n = 151) | CC (n = 78) | LC (n = 59) | MC-NOS (n = 14) | p value* | |
|---|---|---|---|---|---|
| Mean age in years (SD) | 68.0 (9.8) | 69.1 (9.1) | 65.8 (10.2) | 70.6 (10.8) | 0.08 |
| Female sex (%) | 113 (74.8) | 64 (82.1) | 42 (71.2) | 7 (50.0) | 0.03 |
| Married or cohabiting (%) | 99 (65.6) | 45 (57.7) | 44 (74.6) | 10 (71.4) | 0.11 |
| University graduate/professional (%) | 36 (23.8) | 17 (21.8) | 17 (28.8) | 2 (14.3) | 0.43 |
| Mean BMI (SD) | 26.3 (4.8) | 26.5 (5.1) | 26.3 (4.6) | 25.2 (4.2) | 0.69 |
| Tobacco user (%) | 17 (11.3) | 8 (10.3) | 7 (11.9) | 2 (14.3) | 0.89 |
| Alcohol user (%) | 107 (70.9) | 51 (65.4) | 45 (76.3) | 11 (78.6) | 0.31 |
| NSAID use (%) | 52 (34.4) | 29 (37.2) | 20 (33.9) | 3 (21.4) | 0.52 |
| PPI use (%) | 70 (46.4) | 38 (48.7) | 26 (44.1) | 6 (42.9) | 0.83 |
| Any associated drug (%) | 130 (86.1) | 70 (89.7) | 49 (83.1) | 11 (78.6) | 0.37 |
| Coeliac disease (%) | 11 (7.3) | 1 (1.3) | 10 (16.9) | 0 (0.0) | 0.001 |
| Any autoimmune disease (%) | 46 (30.5) | 19 (24.4) | 23 (39.0) | 4 (28.6) | 0.18 |
| Macroscopic features at endoscopy (%) | 18 (11.9) | 10 (12.8) | 7 (11.9) | 1 (7.1) | 0.83 |
| Reporting effective drug therapy (%) | 64 (83.1) | 39 (83.0) | 20 (80.0) | 5 (100) | 0.55 |
| Rome III IBS-type symptoms (%) | 52 (34.4) | 26 (33.3) | 18 (30.5) | 8 (57.1) | 0.16 |
| Mean HADS anxiety score (SD) | 6.3 (4.6) | 6.1 (4.1) | 6.4 (5.0) | 7.7 (5.5) | 0.47 |
| Anxiety categories (%) | |||||
| Normal | 89 (61.0) | 47 (61.0 | 34 (61.8) | 8 (57.1) | |
| Borderline abnormal | 35 (24.0) | 23 (29.9) | 10 (18.2) | 2 (14.3) | |
| Abnormal | 22 (15.1) | 7 (9.1) | 11 (20.0) | 4 (28.6) | 0.14 |
| Mean HADS depression score (SD) | 4.5 (4.3) | 3.9 (3.5) | 5.0 (5.2) | 6.0 (4.2) | 0.14 |
| Depression categories (%) | |||||
| Normal | 118 (79.7) | 66 (85.7) | 43 (75.4) | 9 (64.3) | |
| Borderline abnormal | 17 (11.5) | 8 (10.4) | 6 (10.5) | 3 (21.4) | |
| Abnormal | 13 (8.8) | 3 (3.9) | 8 (14.0) | 2 (14.3) | 0.16 |
| Mean PHQ-15 score (SD) | 9.5 (4.9) | 9.8 (5.0) | 8.8 (4.7) | 11.3 (4.6) | 0.21 |
| PHQ-15 somatization categories (%) | |||||
| Mild | 23 (15.3) | 12 (15.4) | 10 (16.9) | 1 (7.7) | |
| Low | 51 (34.0) | 26 (33.3) | 21 (35.6) | 4 (30.8) | |
| Medium | 54 (36.0) | 27 (34.6) | 21 (35.6) | 6 (46.2) | |
| High | 22 (14.7) | 13 (16.7) | 7 (11.9) | 2 (15.4) | 0.95 |
| Mean SF-36 score (SD) | |||||
| Physical functioning | 63.1 (30.5) | 58.6 (31.7) | 70.4 (26.8) | 55.4 (35.6) | 0.07 |
| Role limitations physical health | 47.1 (44.2) | 50.0 (43.5) | 56.9 (43.6) | 39.6 (47.0) | 0.11 |
| Role limitations emotional problems | 47.1 (44.4) | 62.2 (45.3) | 66.1 (43.8) | 52.8 (43.7) | 0.63 |
| Energy/fatigue | 50.8 (24.2) | 51.6 (24.2) | 53.2 (23.5) | 34.5 (23.4) | 0.06 |
| Emotional wellbeing | 71.1 (20.4) | 72.9 (19.4) | 71.5 (19.8) | 59.1 (25.6) | 0.08 |
| Social functioning | 70.2 (28.0) | 66.3 (28.9) | 77.0 (24.8) | 63.5 (32.1) | 0.06 |
| Pain | 56.4 (27.0) | 54.6 (28.1) | 60.3 (26.6) | 49.2 (21.1) | 0.29 |
*
One-way analysis of variance for continuous data and χ2 for categorical data.
BMI, body mass index; CC, collagenous colitis; HADS, Hospital Anxiety and Depression Scale; IBS, irritable bowel syndrome; LC, lymphocytic colitis; MC, microscopic colitis; MC-NOS, microscopic colitis, not otherwise specified; NSAID, nonsteroidal anti-inflammatory drugs; PHQ-15, Patient Health Questionnaire 15; PPI, proton pump inhibitor; SD, standard deviation; SF-36, Short Form 36.