Table 2.

Cox Proportional Hazards Model to Assess Effects on OS

Covariate	Univariable Analysis				Multivariable Analysis
	Coefficient (B)	HR [expB]	95% CI	P Value	Coefficient (B)	HR [expB]	95% CI	P Value
Age	0.037	1.038	1.008–1.068	.013	0.035	1.036	1.005–1.068	.024
KPS	−0.029	0.972	0.935–1.010	.149	N/A
Gender
Female	0.187	1.206	0.562–2.587	.631	N/A
Male	(reference)
FLAIR volume
Pre-RT	0.005	1.005	0.993–1.018	.414	0.001	1.000	0.987–1.013	.986
Post-RT	0.010	1.010	1.002–1.018	.017	0.008	1.008	1.001–1.016	.043
% Change	0.001	1.000	1.000–1.001	.297	N/A
MGMT status
Unmethylated	0.383	1.467	0.540–3.984	.453	N/A
Methylated	(reference)
IDH-1 status
Unmutated	1.714	5.553	0.736–41.879	.096	N/A
Mutated	(reference)
RT dose
40 Gy	0.794	2.212	0.922–5.306	.075	N/A
60 Gy	(reference)
Extent of resection
Biopsy only	0.792	2.209	0.305–16.002	.433	N/A
Subtotal	0.748	2.112	0.495–9.008	.312
Total	(reference)

Note: Data in bold represent statistical significance (P < .05).

Abbreviations: OS, overall survival; KPS, Karnofsky performance status; HR, hazard ratio; CI, confidence interval.