Table 3.

Cox Proportional Hazards Model to Assess Effects on PFS

Covariate	Univariable Analysis				Multivariable Analysis
	Coefficient (B)	HR [expB]	95% CI	P Value	Coefficient (B)	HR [expB]	95% CI	P Value
Age	0.008	1.008	0.988–1.028	.431	0.002	1.002	0.983–1.021	.849
KPS	−0.017	0.983	0.956–1.012	.254	N/A
Gender
Female	0.113	1.120	0.565–2.220	.746	N/A
Male	(reference)
FLAIR volume
Pre-RT	0.001	1.001	0.990–1.013	.811	−0.012	0.988	0.976–0.999	.042
Post-RT	0.020	1.020	1.011–1.029	<.001	0.026	1.026	1.015–1.038	<.001
% Change	0.001	1.001	1.001–1.002	.001	N/A
MGMT status
Unmethylated	−0.170	0.844	0.367–1.941	.690	N/A
Methylated	(reference)
IDH-1 status
Unmutated	0.189	1.208	0.287–5.084	.796	N/A
Mutated	(reference)
RT dose
40 Gy	0.261	1.298	0.619–2.719	.490	N/A
60 Gy	(reference)
Extent of resection
Biopsy only	−0.523	0.593	0.108–3.257	.633	N/A
Subtotal	0.171	1.186	0.409–3.444	.754
Total	(reference)

Note: Data in bold represent statistical significance (P < .05).

Abbreviations: PFS, progression-free survival; KPS, Karnofsky performance status; HR, hazard ratio; CI, confidence interval