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. 2018 Jun 20;14:1744806918782229. doi: 10.1177/1744806918782229

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Fyn^CA increased current density and caused mild changes in Nav1.7 gating properties in HEK 293 cells. (a) Coexpression of Fyn^CA increased current density of Nav1.7 in HEK 293 cells. The left panel shows the representative raw sodium currents of Nav1.7r cotransfected with Fyn^CA or Fyn^DN, and the right panel is the histogram of mean current densities. Data are presented as means ± SE, *p < 0.05, Fyn^CA versus Fyn^DN by Mann–Whitney test. (b) The activation and steady-state fast inactivation curves of Nav1.7 channels. Expression of Fyn^CA caused a depolarized shift in activation but a hyperpolarized shift in steady-state fast inactivation of Nav1.7 channels in HEK 293 cells. (c) The steady-state slow inactivation of Nav1.7 channels. Fyn^CA had little effect on slow inactivation of Nav1.7 in HEK 293 cells. Data are presented as means ± SE. HEK: Human Embryonic Kidney; WT: wild type.