Table 2.
Inflammatory markers and oxidative stress indicators in patients with liver cirrhosis and healthy subjects.
| Parameters | Liver Cirrhosis | Healthy Subjects (n = 110) |
|
|---|---|---|---|
| Class A (n = 63) |
Class B–C (n = 12) |
||
| Inflammatory markers | |||
| White blood cell (cells/mm3) | 5316.83 ± 2039.96 (5120.0, 3945.0–6550.0) |
5216.00 ± 1953.31 | 5210.00 ± 1599.77 (5100.0, 4300.0–5700.0) |
| Absolute neutrophil count (cells/mm3) | 3410.07 ± 1556.4 (3012.68, 2289.6–4175.35) |
3281.46 ± 1850.12 (3165.50, 2514.5–3411.0) |
2971.63 ± 1170.50 (2823.45, 2332.0–3302.0) |
| Absolute lymphocyte count (cells/mm3) | 1413.51 ± 633.21 | 1315.45 ± 614.77 | 1705.98 ± 577.77 (1657.75, 1328.1–1947.0) |
| Neutrophil/Lymphocyte ratio | 2.90 ± 1.75 a (2.35, 1.63–3.69) |
2.50 ± 1.45 a,b | 1.86 ± 0.85 b (1.69, 1.32–2.17) |
| Absolute monocyte count (cell/mm3) | 362.83 ± 170.03 (311.14, 239.12–471.3) |
513.86 ± 255.30 | 376.53 ± 196.16 (340.4, 283.75–420.60) |
| hs-CRP (mg/dL) | 0.99 ± 3.79 b (0.10, 0.04–0.26) |
2.35 ± 4.77 a (0.75, 0.43–1.86) |
0.06 ± 0.07 c (0.03, 0.01–0.07) |
| Indicators of oxidative stress and antioxidant capacity | |||
| Malondialdehyde (μmol/L) | 0.79 ± 0.19 b (0.76, 0.67–0.90) |
0.93 ± 0.20 a | 0.85 ± 0.19 a,b (0.81, 0.71–0.96) |
| Glutathione (μmol/L) | 77.76 ± 25.41 a | 42.88 ± 27.47 b (42.03,29.98–47.30) |
44.69 ± 17.38 b |
| Glutathione disulfide (μmol/L) | 667.03 ± 70.96 a | 601.22 ± 87.64 b | - |
| GSH/GSSG ratio | 0.12 ± 0.04 a | 0.07 ± 0.04 b | - |
| GSH-Px (nmol/mL/min) | 205.17 ± 68.33 a (206.30, 159.18–237.50) |
183.80 ± 109.49 a,b | 148.05 ± 36.57 b (140.08, 119.71–165.55) |
| GSH-Rd (nmol/mL/min) | 76.73 ± 33.44 b (71.58, 61.84–83.58) |
87.87 ± 23.51 a (83.59, 77.48–89.79) |
- |
| TEAC (μmol/L) | 4227.95 ± 640.79 (4188.40, 3886.14–4534.17) |
4041.76 ± 819.51 | 4290.79 ± 468.35 (4290.93, 3974.34–4590.63) |
Values are means ± standard deviation. The median value and interquartile range are in the parentheses for non-normally distributed values. hs-CRP, high sensitivity C-reactive protein; GSH, glutathione; GSSG, glutathione disulfide; TEAC, Trolox equivalent antioxidant capacity. a,b,c Values with different superscript letter are significantly different among groups; p < 0.05.