Table 2.
Assignment of C1A cysteine proteinase sequences to Babesia, Theileria, and Cytauxzoon species and clades.
1 Piroplasmid lineages are designated as defined by Schnittger et al. [2] by roman numbers. 2 C1A proteinase groups are designated according to those identified in the phylogenetic tree of Figure 1. 3 This C1A proteinase has not been included in the phylogenetic tree since it is truncated but could be confirmed by BBH. C1A proteinases framed blue and green represent in- and out-paralogs, respectively. C1A proteinases designated by an underlined accession numbers within a line represent orthologs as identified either by BBH or by tree analysis with respect to C1A proteinases designated with a bold accession number. C1A proteinases in italics represent non-functional proteinase homologs that exhibit incomplete or exchanged amino acids at active sites.