Table 3.
Toxicokinetic parameters for peptide toxins of beagles in different experimental groups
| Parameter | α-Amanitin | β-Amanitin | Phallacidin | |||
|---|---|---|---|---|---|---|
| 20 mg/kg with Biliary Drainage Group | 60 mg/kg with Biliary Drainage Group | 20 mg/kg with Biliary Drainage Group | 60 mg/kg with Biliary Drainage Group | 20 mg/kg with Biliary Drainage Group | 60 mg/kg with Biliary Drainage Group | |
| T1/2 (h) | 1.08 ± 0.76 | 1.2 ± 0.58 | 1.29 ± 1.07 | 1.54 ± 0.71 | - | 0.62 ± 0.32 b,* |
| AUC (0–∞) (µg/L × h) | 5.36 ± 3.17 | 31.99 ± 9.65 a,* | 3.24 ± 1.49 | 15.75 ± 4.27 a,b | - | 2.08 ± 2.06 b,* |
| Dose normalized AUC (0–∞) | 138.9 ± 82.1 | 238.2 ± 83.9 | 179 ± 82.4 | 222.3 ± 79.2 | - | 60.5 ± 60.2 b,* |
| Cmax (µg/L) | 1.73 ± 0.58 | 12.25 ± 3.54 a,* | 0.85 ± 0.33 | 5.18 ± 1.32 a,b | - | 0.85 ± 0.37 b,* |
| Dose normalized Cmax | 44 ± 15.1 | 86.1 ± 30.8 | 57 ± 18.3 | 96 ± 24.4 | - | 24.8 ± 10.8 b,* |
| Tmax (h) | 1.38 ± 0.48 | 1.13 ± 0.25 | 1.63 ± 0.48 | 1.25 ± 0.29 | - | 1.38 ± 0.25 |
| CL/F (L/h/kg) | 0.85 ± 0.43 | 0.36 ± 0.11 | 0.64 ± 0.42 | 0.33 ± 0.09 | - | 1.1 ± 0.86 b,* |
| Vz/F (L/kg) | 1.07 ± 0.31 | 0.68 ± 0.48 | 0.78 ± 0.63 | 1.38 ± 0.59 | - | 1.77 ± 0.57 b,* |
| MRT (0–∞) (h) | 3.55 ± 0.8 | 2.87 ± 0.43 | 3.83 ± 1.02 | 3.89 ± 0.46 | - | 1.95 ± 0.73 b,* |
We could not calculate the toxicokinetic parameters because phallacidin was not detected in serum in the 20 mg/kg with biliary drainage group. a indicates p ≤ 0.05 when compared to the same toxin in the 20 mg/kg with biliary drainage group. b indicates p ≤ 0.05 when compared to α-amanitin in the same experimental group. * indicates p ≤ 0.05 when compared to β-amanitin in the same experimental group.