Table 1.

Summary of kinase mutations discovered in RDD

Gene	Genetic alteration	Amino acid variant	Protein domain	Discovery year	Reference
ARAF	Missense	p.N217K	CR2 domain	2016	10
MAP2K1	Missense	p.F53V	N-terminal negative regulatory	2017	13
MAP2K1	Missense	p.L115V	N-terminal catalytic core of kinase	2017	14
MAP2K1	Missense	p.P124R	N-terminal catalytic core of kinase	2017	13
MAP2K1	Missense	p.G128D	N-terminal catalytic core of kinase	2017	13
NRAS	Missense	p.G13D	P-loop and GTP-binding 1	2016	10
KRAS	Missense	p.G12D	P-loop and GTP-binding 1	2016	10
KRAS	Missense	p.G12R	P-loop and GTP-binding 1	2017	101
KRAS	Missense	p.Q22K	GTP-binding 1	2017	13
KRAS	Missense	p.K117N	GTP-binding 3	2016	11
KRAS	Missense	p.A146T	GTP-binding 4	2017	13
KRAS	Missense	p.A146V	GTP-binding 4	2017	12