Table 1.
Clinical data of participating patients divided by pre-HSCT treatment regime
| Without conditioning (n = 29) | With conditioning (n = 19) | P | |
|---|---|---|---|
| Age at time of sample, median (minimum-maximum), y | 12.65 (2.68-29.65) | 5.34 (2.17-16.73) | .0034 |
| Time posttransplant at time of sample, median (minimum-maximum), y | 12.63 (2.13-28.44) | 4.59 (1.97-16.73) | .0012 |
| Male sex, n (%) | 28 (97) | 16 (84) | |
| Genotype, n (%) | |||
| IL2RG | 27 (93) | 15 (79) | |
| JAK3 | 2 (7) | 4 (21) | |
| Positive family history, n (%) | 20 (69) | 13 (72)* | |
| Donor type, n (%) | |||
| Mismatched related | 27 (93) | 9 (47) | |
| Unrelated | 1 (3.5) | 10 (53) | |
| Matched other relative | 1 (3.5) | 0 (0) | |
| Age at transplant, mean (standard deviation), d | 122 (106) | 176 (136) | |
| Chimerism, median (minimum-maximum), % | |||
| T cell | 98 (70-100); n = 11 | 100 (64-100); n = 17 | |
| B cell | 2 (0-100); n = 28 | 99 (0-100); n = 16 | |
| Myeloid | 3 (1-100); n = 7 | 100 (4-100); n = 4 | |
| Off intravenous immunoglobulin, n (%) | 9 (31) | 16 (84) | |
| Vaccine status , n (%) | |||
| Not tested | 20 (69) | 4 (21) | |
| Detectable | 2 (7) | 1 (5) | |
| Protective | 7 (24) | 14 (74) |
Percentage of cases within conditioning category.
*
One unknown family history.