Table 3.
Overview of studies using non-primate lentiviral vectors for ocular gene delivery.
| Non-Primate Lentiviral Vector | Target Host Cell/Tissue/Organism | Delivered Genes | References |
|---|---|---|---|
| FIV | Perfused human eyes | lacZ, eGFP | [95,96] |
| FIV | Macaque | lacZ | [97] |
| FIV | Mouse | lacZ, β-glucuronidase | [98] |
| BIV | Mouse | eGFP | [99] |
| EIAV | Rabbit and human corneas, murine corneal endothelial cells | lacZ, eGFP | [100] |
| FIV | Rabbit, rat | lacZ | [101] |
| EIAV | Mouse | eGFP | [102] |
| EIAV | Mouse | lacZ | [103] |
| EIAV | Cryopreserved primary cultured human corneal endothelial cells | eGFP | [104] |
| FIV | Mouse retinal progenitor cells | YFP | [105] |
| FIV | Cat | eGFP/myocilin a, lacZ | [106] |
| EIAV | Mouse | lacZ, human ABCA4 | [107] |
| EIAV | Mouse | endostatin/angiostatin a | [108] |
| FIV | Macaque | eGFP | [109] |
| FIV | Rabbit | NBCe1-shRNA/copepod-GFP a | [110] |
| EIAV (RetinoStat) | Rabbit, macaque | endostatin/angiostatin a | [111] |
| EIAV (StarGen) | Rabbit, macaque | ABCA4 | [112] |
| EIAV (EncorStat) | Rabbit, primate and human corneal tissue | endostatin/angiostatin a | [113,114] |
| EIAV (UshStat) | Mouse, macaque | myo7A | [115] |
| EIAV (RetinoStat) | Human patients | endostatin/angiostatin a | [116] |
a the indicated transcription units were co-delivered from lentiviral vectors bearing bicistronic transgenes.