Figure 2.

Conotoxin structural and functional diversity. (A) Conotoxins have highly diverse sequences, cysteine frameworks, connectivity, and biological targets. χ-MrIA and α-TxIA have the same cysteine framework, but different connectivities and sequence which contribute to the difference in their targets. On the contrary, ω-MVIIC and μO-MrVIB have the same cysteine framework and connectivity but different biological targets. (O = hydroxyproline); (B) Conotoxin diversity extends to their three-dimensional structures, and thereby further adding to their functional diversity.