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A clinical case of EBV-related Hodgkin lymphoma occurring in a patient with HIV infection. Several Reed-Sternberg cells are seen within a mixed inflammatory microenvironment (A). These cells express CD30 (B) and are EBV infected, as demonstrated by LMP1 immunostaining (C) and EBER in situ hybridization (D). Original magnification ×400 (A–D).
