Table 1.
EBV infection in Hodgkin lymphoma according to the immunocompetence status of the host.
| Host | Hodgkin Lymphoma | EBV Infection |
|---|---|---|
| Without known immunosuppression | NLPHL | Usually absent |
| cHL, nodular sclerosis | Variably present | |
| cHL, mixed cellularity | Usually present | |
| Rare cHL subtypes | Variably present | |
| With acquired Immunodeficiency | HIV-associated cHL | Present |
| Post-transplant, cHL type PTLD | Present | |
| Iatrogenic (methotrexate) | Variably present |
cHL, classical Hodgkin lymphoma; NLPHL, nodular lymphocyte predominant Hodgkin lymphoma; PTLD, post-transplant lymphoproliferative disorder.