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Hap1 repression modules (RPMs) promote Hap1 association with Ydj1, Ssa (Hsp70), and Sro9 to form an inactive High Molecular Weight Complex (HMC). Upon heme binding to Heme Responsive Motif 7 (HRM7), Hsp90 is stably bound and the HMC is disrupted, producing the active dimeric complex (DC). In the new complex, the Hap1 acidic activation domains (ACT) are activated and DNA binding is promoted via the DNA binding domains (DBD).
