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At low heme levels, the ZnF region and other proteins (X) repress Gis1 transcriptional and demethylase activities. At higher heme concentrations, heme binds a second site in the ZnF causing loss of X, oligomerization of Gis1, and conformational changes which fully activate Gis1 demethylase and transcriptional activities. JmjN and JmjC: jumonji domains and demethylase activity. TAD1 and TAD2: transcription activation domains. ZnF: C2H2 type zinc fingers.
