Table 3.
Association between air pollution exposure and lung function outcomes.
| Lung Function Outcome | PM2.5 | Ozone | ||||
|---|---|---|---|---|---|---|
| 7-Day Average | 10-Day Average | 14-Day Average | 7-Day Average | 10-Day Average | 14-Day Average | |
| FVC (L) (% change) 1 |
0.86 (−1.71, 3.50) | 0.41 (−2.03, 2.91) | 0.0 (−2.25, 2.31) | 0.59 (−3.51, 4.86) | 0.46 (−3.58, 4.66) | 0.80 (−3.13, 4.88) |
| FEV1 (L) (% change) 1 |
2.17 (−1.28, 5.75) | 1.65 (−1.63, 5.04) | 0.76 (−2.99, 4.70) | 0.57 (−4.83, 6.29) | 1.11 (−4.25, 6.77) | −0.03 (−5.18, 5.40) |
| Episodes of FEV1 > 10% decline 2 | 0.74 (0.18, 1.19) | 0.76 (0.30, 1.22) | 0.85 (0.32, 1.38) | 0.9 (0.02, 1.79) | 0.93 (0.01, 1.85) | 0.98 (0.04, 1.93) |
Adjusted association between short-term air pollution exposure (PM2.5 and ozone) and lung function outcomes in fibrotic sarcoidosis. Shown are 1 percentage change (95% confidence interval) of FEV1 and FVC for each IQR change in air pollution exposure, and 2 odds ratios (95% confidence interval) for episodes of FEV1 decline > 10% for each IQR change in air pollution exposure. Interquartile range (IQR) for PM2.5 averaged over 7, 10, and 14 days = 4.92, 4.64, and 4.38 μg/m3, respectively. IQR for ozone averaged over 7, 10, and 14 days = 0.014, 0.014, and 0.014 ppm, respectively. All models adjusted for age, sex, smoking status, and study drug assignment. PM2.5 = fine particulate matter with diameter less than 2.5 μm; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity.