Table 2. Allele and genotype frequencies of 1q32 SNP rs11584383 in patients with AS and controls (ctls) stratified according to DISQ score and calprotectin level.
| Phenotype | 1q32 genotype | MAF | p | OR [95% CI] | PdifferenceΦ | ||
|---|---|---|---|---|---|---|---|
| DISQ | T/T | T/C | C/C | C | |||
| AS (≤10) | 107 (0.60) | 65 (0.36) | 8 (0.04) | 81 (0.23) | 0.004 | 0.66 [0.50–0.88] | |
| AS (≥11) | 73 (0.61) | 39 (0.33) | 8 (0.07) | 55 (0.23) | 0.020 | 0.68 [0.49–0.95] | 0.893 |
| Ctl | 247 (0.48) | 226 (0.44) | 45 (0.09) | 316 (0.31) | |||
Notes:
DISQ, Dudley Inflammatory Bowel Symptom Questionnaire; MAF, minor allele frequency; p, unadjusted allelic p-value; OR [95% CI], Odds ratio and 95% confidence intervals.
Φ
Pdifference between AS patients with DISQ ≤10 and ≥11.
Ψ
Pdifference between AS patients with calprotectin 0–149 and ≥150. A faecal calprotectin of ≥150 g/kg was considered to represent definite bowel inflammation.