Figure 7.

Overview of antibody-like proteins specific to Human Epidermal growth factor Receptor 2 (HER2) which have been genetically integrated into Adenovirus. HER2 is composed of 4 domains, Extra Cellular Domain (ECD) I-IV which can be bound by different proteins (A). The Designed Ankyrin Repeat Proteins (DARPIN’s) 9.29 (B) and G3 (C) are seen in orange and red complexing ECD-I and ECD-IV, respectively. ScFv chA21 (D) is seen in purple complexing ECD-1 (this particular ScFv has not previously been integrated to Adenovirus), and affibody ZHER2 (E) is seen in green binding at the ECD-III/IV interface. All molecules are shown to scale, structures from PDB: 4HRL, 4HRN, 3H3B, and 3MZW.