Figure 2.

Systemically delivered rTSR1 suppressed B16F10 tumor growth in mice. (A) Tumor growth curve from day 9 to 15 post tumor cell injection (n = 5). Data represents mean ± SD. The rTSR1 was systemically delivered through intra-peritoneal (IP) injection. Statistical analysis performed by Student’s t test. * p < 0.05; (B) Tumor weight at the end of experiment, control and rTSR1 treated group, n = 5 for each group. The graph represents the mean ± SD of the tumor weight. Statistical analysis performed by Student’s t test. * p < 0.05; (C) Dissected tumor nodules from control and rTSR1 treated groups—scale bar: 1 cm; (D) rTSR1-treated mice showed a reduced peri-tumor vascular network compared to tumors of similar sizes in the control group—scale bar: 0.5 cm. Arrows indicate the blood vessels surrounding the tumor.