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The rTSR1 suppressed tumor endothelial cell proliferation. Representative microscopic images show decreased proliferating endothelial cells in an rTSR1-treated tumor compared to the control. Green indicates the endothelial cells (endomucin-positive), and red indicates the nuclear PCNA-positive proliferating cells. DAPI (4′,6-diamidino-2-phenylindole) was used as the nuclear counter stain. The arrow heads indicate the nuclear PCNA-positive tumor endothelial cells. Scale bar: 30 μm.
