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Framework of 12-hour clock study. (A) Diagram summarizing the potential causal roles of mammalian 12-hour clock in disease development with future directions outlined below. Twelve-hour rhythms can be disrupted either by the dampening of the amplitude or alteration of the period. (B) Diagram summarizing the basis for biological system being part of “musica universalis”. ERSE, ER response element; RORE, retinoic acid–related orphan receptor response element.
