. 2018 Mar 28;55(4):862–870. doi: 10.1093/jme/tjy022

Table 2.

Insecticide resistance in mosquitoes microinjected with RNAi to silence specific genes

Target gene	RNAi	S-Lab		HAmCq^G0		MAmCq^G0
Target gene	RNAi	LC₅₀¹ (CI)²	Ratio³ (mean ± SE)	LC₅₀¹(CI)²	Ratio³ (mean ± SE)	LC₅₀¹ (CI)²	Ratio³ (mean ± SE)
Control	No-injection	0.0033 ± 0.0002^a	1	0.005 ± 0.001^a	1	0.028 ± 0.009^a	1
Control	GFP-injection	0.0032 ± 0.0005^a	0.97 ± 0.01	0.004 ± 0.001^a	0.80 ± 0.09	0.031 ± 0.016^a	1.11 ± 0.21
GPCR020021	GPCR020021- injection	0.0020 ± 0.0001^b	0.61 ± 0.02	0.003 ± 0.0005^b	0.60 ± 0.10	0.019 ± 0.001^b	0.67 ± 0.02
Gαs006458	Gαs006458- injection	0.0013 ± 0.0005^b	0.39 ± 0.07	0.002 ± 0.0004^b	0.41 ± 0.04	0.005 ± 0.001^b	0.17 ± 0.05
AC007240	AC007240-injection	0.0012 ± 0.0004^b	0.36 ± 0.06	0.002 ± 0.0003^b	0.40 ± 0.04	0.011 ± 0.007^b	0.36 ± 0.04
AC004739	AC004739-injection	0.0009 ± 0.0002^b	0.27 ± 0.03	0.002 ± 0.0005^b	0.40 ± 0.05	0.010 ± 0.005^b	0.36 ± 0.05
PKA000798	PKA000798- injection	0.0019 ± 0.0010^b	0.58 ± 0.16	0.001 ± 0.0004^b	0.24 ± 0.05	0.012 ± 0.003^b	0.43 ± 0.06
PKA018257	PKA018257- injection	0.0014 ± 0.0006^b	0.42 ± 0.08	0.002 ± 0.0007^b	0.37 ± 0.06	0.014 ± 0.003^b	0.51 ± 0.06

¹LC₅₀ values in ppm

²95% CI, toxicity of insecticide is considered significantly different when the 95% CI fail to overlap; no significant difference (a) and significant difference (b) compared with no-injection mosquitoes.

³Ratios were calculated by dividing the LC₅₀ of the GFP or target gene injection mosquito groups by the LC₅₀ of the non-injection mosquito group of same mosquito strain.