Figure 2.

Primary mechanisms of tumor specificity for oncolytic virotherapies in multiple myeloma. (a) For RV, CV and MV tumor specificity is dictated by their respective receptors, each of which is overexpressed in MM; (b) Deficiencies in IFN signaling and PKR activity, which are common in MM, provide tumor specificity for VSV; (c) VV tumor specificity is driven by engineered deletions in the vaccinia genome that eliminate genes essential for viral replication in normal cells. Additional mechanisms of tumor specificity exist for many of the viruses depicted; see the text for details.