Figure 1.

SERT Binding Densities. MAO inhibition with combined clorgyline and deprenyl (AB), as described in detail in the text, reduced SERT binding in the cortex (F_3,52 = 3.59, p = 0.02) and the raphe nuclei (F_3,51 = 6.07, p = 0.0015) in both a time- and treatment-dependent fashion. Significant pairwise time x treatment effects (p < 0.05) are indicated by *. In the cortex, AB was significantly different from all other groups (post-hoc p < 0.05); in raphe, AB was significantly different from C and A, and B was also significantly different from C (post-hoc p < 0.05). Six animals were examined for each treatment and each time point; error bars S.E.M.