Table 2.

Control Levels of Serotonin and Dopamine Transporters during Postnatal Development.

		Serotonin Transporter, fmol/mg Tissue
PND	Striatum	Hippocampus		Cortex		Raphe		Sub nigra
14	0.39 ± 0.07	0.42 ± 0.19		0.42 ± 0.14		1.54 ± 0.31		1.47 ± 0.23
35	1.03 ± 0.16	0.89 ± 0.15		0.73 ± 0.12		1.57 ± 0.18		2.31 ± 0.35
90	1.10 ± 0.10	0.95 ± 0.09		0.84 ± 0.09		1.7 ± 0.37		2.07 ± 0.18
	Dopamine Transporter, fmol/mg Tissue
PND	Nuc accumbens		Striatum		Loc coeruleus		Sub nigra
14	1.29 ± 0.31		1.35 ± 0.18		0.91 ± 0.13		0.8 ± 0.09
35	1.30 ± 0.07		1.39 ± 0.06		0.75 ± 0.2		0.71 ± 0.06
90	1.64 ± 0.16		1.66 ± 0.13		0.61 ± 0.02		0.83 ± 0.15

Densities of SERT and DAT (expressed as fmol/mg tissue) were measured by radioreceptor binding, as described in detail in Methods. In control animals, SERT density increased significantly between postnatal days 14 and 90 in cortex (F_2,13 = 18.87, p = 0.0001), hippocampus (F_2,13 = 19.58, p = 0.0001), striatum (F_2,14 = 60.93, p < 0.0001) and substantia nigra (F_2,14 = 14.05, p = 0.0004). Raphe levels of SERT did not increase significantly between days 14 and 90. There were no significant changes in DAT levels between 14 and 90 days post-natal.