. 2018 Jun 4;16(6):194. doi: 10.3390/md16060194

Table 1.

Novel natural products isolated from extremophilic fungi.

The Type of Compound	Compounds	Biological Activity	References
*Terpenoids and steroids*	*23, 24 , 25–28**	Cytotoxic	[25]
	*(39–41) , 42, 43 , 44, 45*	Cytotoxic and/or antiviral	[29,30]
	(145–150) , 154, 155 , 156, 157 *	Cytotoxic and/or antimicrobial	[52,53,56,57]
	176 , 177–179, 180 , 181–183, 184 *	Cytotoxic	[62,63]
	190, 191		[66]
	*200 , 201–204**	Antiviral	[69]
	208		[70]
	209	Antiallergic	[71]
	245		[80]
	*288 , 289–292, 293 , 294, 295, 296 , 297, 298**	Induce cAMP production	[91]
	299 , 300	Inhibit MMP-3 and Casp-1 and/or cytotoxic	[92]
	*309 , 310 , 311*	Mitigate IL-1β production	[97]
*Alkaloids, peptides, and amides*	10, 11 , 12, 13, 14	Anti-inflammatory	[24]
	*15 , 16, 17 , 18 , 19–22**	Cytotoxic	[25,26]
	29–33		[27]
	(47–55) *	Insecticidal	[32]
	73		[36]
	*74 , 75, 76**	Inhibit α-glucosidase	[37]
	*86 , 87 , 88, 89*	Antimicrobial	[40]
	104, 105		[43]
	108, 112		[44]
	(124–135) , 136–138, (139–142)	Antiviral or antimicrobial	[48,49]
	144 *	Cytotoxic	[51]
	*151 , 152, 153**	Cytotoxic	[55]
	*(167–169) , 170–173**	Cytotoxic	[60]
	185		[63]
	187–189		[65]
	*192 , 193 , 194, 195, 196 , 197**	Reduce intracellular lipid accumulation	[67]
	198, 199 *	Antimicrobial	[68]
	*221 , 222 , 223–226*	Nematicidal	[74,75]
	233 , 234	Cytotoxic	[77]
	(248–258) , 259, (260–262)	Radical-scavenging and/or cytotoxic	[82,83]
	(265–268) *	Antimicrobial	[85]
	(269–272) , 273–275, 276 , 277, 278, 279 , 280, 281, 282	Antimicrobial and/or cytotoxic	[86,87,88]
	286, 287		[90]
	(305–308) *	Inhibit MMP-3 and Casp-1	[96]
	312 , 313	Inhibit MMP-3 and Casp-1, and mitigate IL-1β production	[98]
*Quinones and phenols*	46		[31]
	56		[33]
	*63–67, 68 , 69–71**	Antimicrobial and cytotoxic	[35]
	77	Cytotoxic	[38]
	79 , 80 , 81, 82 , 83, 84 , 85 *	Cytotoxic	[39]
	*94–97, 98 , 99**	Activate Nrf2	[41]
	*106 , 107**	Antilarval	[43]
	109, 110 , 111	Inhibit BRD4	[44]
	114–119		[46]
	143 *	Antimicrobial	[50]
	*158–160, 161 , 162 , 163–166*	Antimicrobial	[58,59]
	246 , 247	Cytotoxic	[81]
	*263 , 264**	Radical-scavenging	[84]
*Esters and lactones*	78		[38]
	207 *	Inhibit PTP1B	[70]
	*227 , 228 , 229–232*	Nematicidal	[76]
	*283 , 284 , 285*	Cytotoxic	[89]
	(302–304) *	Cytotoxic and/or inhibit MMP-3	[94]
*Xanthones*	57 , 58, 59 , 60 *	Antimicrobial	[34]
	61, 62		[35]
	72		[36]
	90–93		[40]
*Polyketides*	100, 101, 102 , 103	Cytotoxic	[42]
	120–122, 123 *	Cytotoxic	[47]
	*174 , 175**	Inhibit NF-κB	[61]
	186 *	Antimicrobial	[64]
	*(210–212) , 213, 214**	Cytotoxic	[72]
	215, 216, (217–220) *	Cytotoxic	[73]
	235–241, 242 , 243	Cytotoxic	[78]
*Others*	(1–9) *	Cytotoxic	[20,21,22,23]
	(34–38) *	Antimicrobial	[28]
	113 *	Antimicrobial	[45]
	205 , 206	Antiviral	[69]
	244 *	Antimicrobial	[79]
	301 *	Inhibit MMP-3 and Casp-1	[93]
	314		[98]

* bioactive compounds.