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Betulin inhibited RANKL-induced bone resorption by osteoclasts. (A) BMMs were plated on an Osteo Assay Plate and treated with 10 ng/mL RANKL and 30 ng/mL M-CSF in the presence of different concentrations of betulin. Following 4 days of culture, the attached cells on the Osteo Assay Plate were removed and photographed under a light microscope; (B) Pit areas were quantified using the ImageJ program. **, p < 0.01; ***, p < 0.001 (n = 3).
