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Overview of selected TRPC1/4/5 inhibitors.
| Compound Name | Targets (IC50; Activator) | Potential Off-Targets | Comments | References |
|---|---|---|---|---|
| Pico145/HC-608 | TRPC1/4/5 (0.03–1.3 nM; (−)EA) | Not known | Highly selective; suitable for in vivo use | [19,66,67] |
| HC-070 | TRPC1/4/5 (0.3–2 nM; La3+ or carbachol/muscarinic receptors) | Not known | Highly selective; suitable for in vivo use | [66,67] |
| AC1903 | TRPC5:C5 (14.7 µM) | Not known | No known effect on TRPC4:C4, TRPC6:C6 and kinases; suitable for in vivo use | [71] |
