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. 2018 Jun 7;16(6):200. doi: 10.3390/md16060200

Figure 1.

Figure 1

Intracellular expression of Tachypleus tridentatus lectin (TTL) in oncoVV-TTL infected cancer cells and the efficacy of oncoVV-TTL against hepatocellular carcinoma in vivo. (a) The expression of FLAG tagged TTL was determined by Western blot with an antibody against FLAG. Tubulin served as the loading control. (b) MHCC97-H cells were injected into the Balb/c nude mice. Mice were injected with PBS, oncoVV, or oncoVV-TTL after tumor size reached 120 mm3. Arrows indicate two injections. Values are displayed as mean tumor size ±SEM. Statistically significant differences between treatments were represented by asterisks (* p < 0.05). Tumor growth curve of MHCC97-H tumors treated by different injections. (c) Representative MHCC97-H tumors 44 days after first treatment. Mice were imaged using the IVIS imaging system. (d) Quantification of fluorescence intensity of the MHCC97-H tumors 44 days after first treatment.