Table 2.
Mean baseline demographics.
| Fibrosis | NAS | NASH | NASH + Fibrosis | |||||
|---|---|---|---|---|---|---|---|---|
| Improve (n = 57) | Progress (n = 71) | Improve (n = 68) | Progress (n = 77) | Improve (n = 50) | Progress (n = 81) | Improve (n = 39) | Progress (n = 73) | |
| Age, year; (mean (SD)) | 13 (2.2) | 13 (3) | 13 (2) | 13 (3) | 12.9 (±2.0) | 13 (3) | 12.6 (1.7) | 13 (3) |
| Female (n (%)) | 46 (81%) | 60 (85%) | 56 (82%) | 62 (81%) | 42 (84%) | 66 (82%) | 34 (87%) | 59 (81%) |
| Ethnicity (n (% Hispanic)) | 36 (63%) | 46 (65%) | 46 (68%) | 47 (61%) | 34 (68%) | 49 (61%) | 26 (67%) | 47 (64%) |
| BMI z-score (mean(SD)) | 2.7 (0.6) | 2.7 (0.7) | 2.6 (0.7) | 2.8 (0.6) | 2.7 (0.7) | 2.8 (0.7) | 2.6 (0.7) | 2.7 (0.6) |
| ALT (U/L; mean(SD)) | 132 (75) | 138 (70) | 144 (84) | 122 (62) | 126 (72) | 139 (71) | 128 (79) | 147 (71) |
| Pre-Pubertal (n (%)) | 25 (44%) | 39 (55%) | 14 (21%) | 58 (75%) | 17 (34%) | 48 (59%) | 14 (36%) | 38 (52%) |
| Fibrosis (n (%)) | ||||||||
| 0 | 0 (0%) | 18 (25%) | 14 (21%) | 19 (25%) | 10 (20.0%) | 15 19%) | 0 (0%) | 12 (16%) |
| 1 | 30 (53%) | 34 (48%) | 24 (35%) | 40 (52%) | 26 (52.0%) | 33 (41%) | 25 (64%) | 31 (43%) |
| 2 | 15 (26%) | 10 (14%) | 17 (25%) | 9 (12%) | 8 (16.0%) | 17 (21%) | 8 (21%) | 16 (22%) |
| 3 | 12 (21%) | 9 (13%) | 13 (19%) | 8 (10%) | 6 (12.0%) | 15 (19%) | 6 (15%) | 14 (19%) |
| NAS (n (%)) | ||||||||
| 2 | 1 (1.8%) | 4 (6%) | 1 (2%) | 7 (9%) | 0 (0.0%) | 4 (5%) | 0 (0%) | 2 (3%) |
| 3 | 10 (18%) | 8 (11%) | 7 (10%) | 16 (21%) | 9 (18%) | 10 (12%) | 7 (18%) | 7 (10%) |
| 4 | 12 (21%) | 22 (31%) | 15 (22%) | 24 (31%) | 13 (26%) | 21 (26%) | 10 (26%) | 17 (23%) |
| 5 | 19 (33%) | 12 (17%) | 16 (24%) | 16 (21%) | 10 (20%) | 21 (26%) | 10 (26%) | 19 (26%) |
| 6 | 12 (21%) | 12 (17%) | 16 (24%) | 10 (13%) | 14 (28%) | 12 (15%) | 10 (26%) | 14 (19%) |
| 7 | 3 (5%) | 12 (17%) | 12 (18%) | 4 (5%) | 4 (8%) | 12 (15%) | 2 (5%) | 13 (18%) |
| 8 | 0 (0%) | 1 (1%) | 1 (2%) | 0 (0%) | 0 (0%) | 1 (1%) | 0 (0%) | 1 (1%) |
| NASH (n (%)) | 5 (9%) | 11 (16%) | 7 (10%) | 20 (26%) | 0 (0%) | 14 (17%) | 0 (0%) | 0 (0%) |
SD: standard deviation; BMI: body mass index.