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. 2018 Jun 28;19:249. doi: 10.1186/s12859-018-2257-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Concept of MICOP. A conceptual diagram of MICOP is shown. a Scheme of MICOP, b Typical results of MICOP. Left boxes: experimental data (red) and reference sin curves (blue); right boxes: scatter plots between reference sin curve (x-axis) and experimental data (y-axis); top: typical oscillating data (MIC = 0.1, P < 0.05); middle: nonoscillating data (MIC = 0.22, P > 0.05); bottom: decaying oscillating data (MIC = 0.94, P < 0.05)