Skip to main content
. Author manuscript; available in PMC: 2018 Jun 29.
Published in final edited form as: Neuroscience. 2014 Apr 20;270:226–235. doi: 10.1016/j.neuroscience.2014.04.020

Figure 3.

Figure 3

Microinjection of carbachol in the left LH produced dose-dependent increases in left PWL. Following a baseline response latency measurement at time −1 min, normal saline (◆) or carbachol in one of three doses: 125 nmol (△); 250 nmol (□); or 500 nmol (○) was microinjected into the LH at time 0. The 500 nmol dose was the most effective across groups compared to saline control rats, but dose response was dependent on sex of the rat and pain condition. Female CCI rats (A) showed equivalent responses to the three carbachol doses, while male CCI rats (B) showed more variability for dose and a smaller, but significant, response to LH stimulation than females. However, nociceptive females responded only to the 500 nmol dose (C), while nociceptive males responded to all carbachol doses (D). Mean response latencies ± SEM are plotted on the ordinate as a function of time (min).