Table 5.

Stratified analyses between miRNA-146a rs2910164 C>G polymorphism and EGJA risk by sex, age, smoking status, and alcohol consumption

Variable	miRNA-146a rs2910164 C>G (case/control)a			Adjusted ORb (95% CI); P-value
	CC	CG	GG	CC	CG	GG	CG/GG	GG vs (CG/CC)
Sex
Male	235/458	396/566	115/167	1.00	1.30 (1.06–1.59); P: 0.012	1.29 (0.97–1.71); P: 0.082	1.36 (1.12–1.65); P: 0.002	1.13 (0.87–1.46); P: 0.363
Female	92/186	147/221	56/76	1.00	1.23 (0.89–1.69); P: 0.215	1.35 (0.88–2.06); P: 0.171	1.39 (1.02–1.89); P: 0.040	1.25 (0.85–1.83); P: 0.263
Age
<64	153/335	256/374	73/114	1.00	1.39 (1.09–1.79); P: 0.009	1.32 (0.93–1.88); P: 0.121	1.48 (1.16–1.88); P: 0.001	1.12 (0.81–1.55); P: 0.481
≥64	174/309	287/413	98/129	1.00	1.18 (0.93–1.49); P: 0.176	1.28 (0.93–1.76); P: 0.136	1.27 (1.01–1.59); P: 0.042	1.18 (0.89–1.58); P: 0.250
Smoking status
Never	228/506	398/614	128/201	1.00	1.33 (1.09–1.63); P: 0.004	1.30 (0.99–1.70); P: 0.058	1.43 (1.18–1.73); P<0.001	1.13 (0.89–1.44); P: 0.325
Ever	99/138	145/173	43/42	1.00	1.09 (0.77–1.53); P: 0.638	1.37 (0.83–2.27); P: 0.221	1.16 (0.83–1.62); P: 0.376	1.32 (0.83–2.10); P: 0.247
Alcohol consumption
Never	282/585	461/697	144/223	1.00	1.28 (1.06–1.53); P: 0.009	1.24 (0.96–1.59); P: 0.097	1.36 (1.14–1.62); P<0.001	1.11 (0.88–1.39); P: 0.392
Ever	45/59	82/90	27/20	1.00	1.11 (0.67–1.85); P: 0.680	1.72 (0.84–3.54); P: 0.142	1.22 (0.75–1.99); P: 0.425	1.61 (0.84–3.08); P: 0.151

Notes:

^aFor miRNA-146a rs2910164 C>G, the genotyping was successful in 1,063 (97.93%) EGJA cases and 1,677 (99.82%) controls;

^bAdjusted for multiple comparisons (age, sex, smoking status, and alcohol consumption [besides stratified factors accordingly]) in a logistic regression model. Bold values are statistically significant (P<0.05).

Abbreviations: EGJA, esophagogastric junction adenocarcinoma; OR, odds ratio.