Table 6.
Logistic regression analyses of association between miRNA-146a rs2910164 C>G polymorphism and lymph node status in EGJA patients
| Genotype | Positive (n=625)
|
Negative (n=438)
|
Crude OR (95% CI) | P-value | Adjusted ORa (95% CI) | P-value | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| miRNA-146a rs2910164 C>G | ||||||||
| CC | 185 | 30.18 | 142 | 33.18 | 1.00 | 1.00 | ||
| CG | 327 | 53.34 | 216 | 50.47 | 1.17 (0.89–1.53) | 0.264 | 1.16 (0.88–1.52) | 0.299 |
| GG | 101 | 16.48 | 70 | 16.36 | 1.11 (0.77–1.61) | 0.571 | 1.10 (0.76–1.60) | 0.613 |
| CG+GG | 428 | 69.82 | 286 | 66.82 | 1.15 (0.88–1.50) | 0.305 | 1.14 (0.87–1.48) | 0.352 |
| CC+CG | 512 | 83.52 | 358 | 83.64 | 1.00 | 1.00 | ||
| GG | 101 | 16.48 | 70 | 16.36 | 1.01 (0.72–1.41) | 0.959 | 1.01 (0.72–1.41) | 0.975 |
| G allele | 529 | 43.15 | 356 | 41.59 | ||||
Notes:
a
Adjusted for age, sex, alcohol use, and smoking status.
Abbreviations: EGJA, esophagogastric junction adenocarcinoma; OR, odds ratio.